William L. Lowe Jr., MD

MD Professor of Medicine and Vice Dean for Academic Affairs
Feinberg School of Medicine, Northwestern University
Division of Endocrinology, Metabolism, and Molecular Medicine

Biographical Sketch:
Dr. Lowe graduated from the University of North Carolina School of Medicine and completed internal medicine training at Beth Israel Hospital in Boston and clinical and research training in Endocrinology and Metabolism in the Diabetes Branch at the National Institutes of Health. After serving as a member of the faculty of the University of Iowa, he joined the Division of Endocrinology, Metabolism, and Molecular Medicine in the Department of Medicine at the Northwestern University Feinberg School of Medicine. He is currently a Professor of Medicine at Northwestern. At Northwestern, he has served as Program Director of the General Clinical Research Center, Vice Chair for Research of the Department of Medicine, Interim Chair of Medicine, and now Vice Dean for Academic Affairs. He has also served as Deputy Director of the Northwestern University Clinical and Translational Sciences Institute. Dr. Lowe has maintained an active translational research program. He has a longstanding interest in the areas of diabetes and metabolism. One of his active areas of interest is cell replacement therapy as a treatment for type 1 diabetes. Working collaboratively with an interdisciplinary team which includes investigators with expertise in bioengineering and transplantation, he and his colleagues are seeking to develop bioactive scaffolds as a platform for islet transplantation. Another area of interest is the genetics of complex diseases and traits, with a specific interest in the genetics of maternal metabolism during pregnancy, fetal growth and their interaction. Having participated in the NIH-funded Gene Environment Interaction Genome Wide Association initiative (GENEVA), he and his collaborators are further characterizing genetic loci associated with maternal metabolic traits during pregnancy and fetal metabolic and growth-related traits. In newer studies, he is using metabolomics to identify metabolic signatures characteristic of maternal hyperglycemia and fetal adiposity at birth.
Papers:
Higher amino acid levels in maternal hyperglycemia: role of genetic variation in enzymatic degradation pathways?
OR51-4 Genes Associated with Obesity in Adulthood Are Associated with Newborn Birth Weight and Adiposity
S36 Islet Cells: Bench to Bedside
S36-3 Advancing Islet Transplantation