S09-1 Obesity, Glycation & Links to Insulin Resistance in Polycystic Ovary Syndrome

Program: Symposia
Session: S09-Obesity & PCOS
Translational
Saturday, June 21, 2014: 9:30 AM-11:00 AM
Presentation Start Time: 9:30 AM
W470 (McCormick Place West Building)
Evanthia Diamanti-Kandarakis, MD, PhD
Athens University Medical School, Athens, Greece
Talk Description:

Obesity, Glycation and Insulin resistance in Polycystic Ovary Syndrome Evanthia Diamanti-Kandarakis MD,PhD, Professor of Medicine-Endocrinology&Metabolism, Head of Third Dep.of Medicine Endocrine section Medical School University of Athens-Greece Polycystic ovary syndrome (PCOS) is a complex and enigmatic syndrome of unknown aetiology, enclosing a broad spectrum of phenotypic manifestations. PCOS pathophysiology combines reproductive and metabolic abnormalities into a heterogeneous disorder that has pervasive health consequences, like type 2 diabetes, metabolic syndrome and increased risk for cardiovascular disease. Affected women have marked insulin resistance and elegant studies have shown that there is a post-binding defect in receptor signaling that selectively affects mainly metabolic pathways in classic and non classic insulin target tissues. Obesity plays a significant aggravating role but beyond calorie excess, the high intake of dietary advanced glycation end products (AGEs) may also contribute to the pathogenesis and perpetuation of PCOS. Experimental evidence in female rats suggests that dietary AGEs are absorbed and deposited in ovarian tissue associated with hypeandrogenemia and insulin resistance. Furthermore, increased AGEs levels were reported in lean, normoglycemic insulin resistant women with PCOS and AGEs were found to be accumulated in human polycystic ovaries. In conclusion obesity as well as advanced glycation end products (AGEs) and other acquired factors ,interfere with insulin action and appear to interplay in the pathogenesis of this multifaceted syndrome. References: Diamanti-Kandarakis, E. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 2012 Diamanti-Kandarakis, E. and Papavasiliou, A.Molecular mechanisms of insulin resistance in polycystic ovary syndrome. (2006) Trends Mol Med 12,324-332 Evanthia Diamanti-Kandarakis (2008) Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications. Expert Rev. Mol. Med. Vol. 10, e3,

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