Session: SUN 0875-0890-Adipocyte Biology-Clinical studies
Poster Board SUN-0887
Helmsley Charitable Trust Abstract Awards in Type 1 Diabetes
In this study, we examined the impact of controlled temperature acclimatization on BAT and energy homeostasis in five men (21±2 years old, BMI: 22±1 kg/m2, body fat: 21±2%) over a 4-month period. Volunteers engaged in usual daytime activities but slept in a temperature-adjusted private room: 24°C (month 1) → 19°C (month 2) → 24°C (month 3) → 27°C (month 4). Personal temperature detectors monitored individual exposed temperature continuously for the entire 4-month period. At the end of each testing month, BAT was quantified by Positron Emission Tomography (PET)-CT scanning and energy metabolism by whole room indirect calorimetry, mixed meal test, blood hormonal/substrate profiling and adipose/muscle biopsies ex vivo analyses.
During the 4-month period, mean BAT volume and overall fat metabolic activity increased upon cold acclimatization (19°C) by 42±18% (p<0.05) and 10±11% (p<0.05), respectively; decreased after the thermoneutral month (24°C) to nearly baseline level, and completely muted at the end of one-month warm exposure (27°C). Room (p<0.05) and individually exposed temperatures (p<0.01), but not outdoor temperatures, correlated with BAT changes during study period. BAT-acclimatization was accompanied by diet-induced thermogenesis and post-prandial glucose metabolism enhancement, evident only after cold exposure. Mechanistically, BAT acclimatization was associated with reciprocal changes of circulating adiponectin and leptin levels, mirrored by corresponding transcriptosomal changes in adipose tissue ex vivo.
In summary, sequential monthly acclimatization modulated BAT reversibly, boosting and suppressing its abundance and activity in mild cold and warm conditions, respectively, independent of seasonal fluctuations. The inducibility and suppressibility of human BAT paralleling whole body metabolic changes suggests regulatory links between BAT thermal plasticity and glucose metabolism in humans. We propose BAT enhancement as a promising therapeutic strategy to improve glycemia in humans.
Nothing to Disclose: PL, SS, JDL, ABC, RJB, WD, CDW, KC, FSC
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