Diverse Impact of Ageing on Insulin Resistance in Lean and Obese and Women with Polycystic Ovary Syndrome: Evidence from 1345 Women with the Syndrome

Program: Abstracts - Orals, Poster Preview Presentations, and Posters
Session: SUN 0001-0029-Female Reproductive Endocrinology II
Sunday, June 22, 2014: 1:00 PM-3:00 PM
Hall F (McCormick Place West Building)

Poster Board SUN-0006
Sarantis Livadas, MD, PhD1, Anastasios Kollias1, Dimitrios Panidis, MD, PHD2 and Evanthia Diamanti-Kandarakis, MD, PhD1
1Athens University Medical School, Athens, Greece, 2Aristotle Univ Thessaloniki, Thessaloniki, Greece
Polycystic ovary syndrome (PCOS) represents a moving spectrum of hormonal towards metabolic abnormalities as women with the syndrome are ageing. Hormonal abnormalities, anovulation and hyperandrogenic signs dominate the picture during the early years of PCOS and fade away as years go by. Metabolic abnormalities and insulin resistance remain throughout the PCOS life cycle, however it is unclear how they change as women with the syndrome are ageing. We undertook the present study aiming to evaluate in a large cohort of women with PCOS and controls, as they are ageing, changes of insulin resistance, assesd with the use fo HOMA-IR index, and its associations with clinical, biochemical, hormonal and ultrasound findings. Data from 1345 women with PCOS (Rotterdam criteria) and 302 controls of Caucasian origin and Greek ethnicity were analyzed on a cross-sectional manner. In PCOS group, age (-0.045±0.008) was negatively and BMI positively (0.18±0.007) associated with HOMA-IR (R2=0.36). When data were stratified regarding BMI status, a negative association of age with HOMA-IR was found in lean, normal and overweight patients (r:-0.266, -0.233, -0.192, p<0.001), which was neutralized in obese patients (r:-0.009, p:ns). Free androgen index and BMI were positively associated with HOMA-IR in all age quartiles. When mean HOMA-IR values were plotted according to BMI subgroups at different age quartiles, a significant gradual decrease of HOMA-IR was observed in normal (p<0.001) and overweight (p:0.004), but not in obese women (p:0.202) across age quartiles. In conclusion, ageing deteriorates insulin resistance in obese but not in lean and overweight women with PCOS. Since BMI and androgens are positively associated with HOMA-IR and androgens decline through time, it appears that if women with PCOS do not become obese may exhibit a better metabolic profile during reproductive years.

Nothing to Disclose: SL, AK, DP, ED

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