Prevalence and Impact of Hyperandrogenemia in 1218 Women with Polycystic Ovary Syndrome

Program: Abstracts - Orals, Poster Preview Presentations, and Posters
Session: SAT 0036-0066-Female Reproductive Endocrinology III
Clinical/Translational
Saturday, June 21, 2014: 1:00 PM-3:00 PM
Hall F (McCormick Place West Building)

Poster Board SAT-0039
Sarantis Livadas, MD, PhD1, Christos Pappas1, Athanasios Karachalios1, Evangelos Marinakis1, Nikoleta Tolia1, Maria Drakou1, Phillipos Kaldrymides1, Dimitrios Panidis, MD, PHD2 and Evanthia Diamanti-Kandarakis, MD, PhD1
1Athens University Medical School, Athens, Greece, 2Aristotle Univ Thessaloniki, Thessaloniki, Greece
Hyperandrogenemia modifies phenotypic characteristics of women with polycystic ovary syndrome (PCOS). The aim of the present study was to evaluate a) the prevalence of hyperandrogenemia in PCOS women (Rotterdam criteria), and b) the impact of either the degree or the type of hyperandrogenemia on phenotype. For this purpose anthropometric, clinical, hormonal, metabolic and ultrasound characteristics of 1218 women with PCOS were analyzed in this cross-sectional study. We have found that the prevalence of hyperandrogenemia was 58.8%. Women with hyperandrogenemia had higher luteinizing hormone (LH), follicle stimulating hormone (FSH), free androgen index, lower sex hormone binding globulin (SHBG) and fasting glucose levels compared to women with normal androgens (p<0.001 for all comparisons, p=0.001 for fasting glucose). Regarding the presence of isolated hyperandrogenemia, the group with only elevated testosterone (T) levels was termed GT and an analogous categorization was made for dehydroepiandrosterone sulfate (DHEAS) [GD] and androstenedione (Δ4) [GΔ4], respectively. GT, GD and GΔ4 comprised the 17.2%, 7,6% and 4,1% of total cohort, respectively. These groups differed significantly between them in LH, LH/FSH ratio, and SHBG (p<0.001). inconclusion, hyperandrogenemia is found in almost 60% of women with PCOS (Rotterdam criteria) and it affects hormonal characteristics of these women such as LH and SHBG values. Regarding the impact of isolated hyperandrogenemia on PCOS characteristics it appears that Δ4 and testosterone elevations are associated with increased LH levels.

Nothing to Disclose: SL, CP, AK, EM, NT, MD, PK, DP, ED

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