Session: MON 0001-0021-Effects of Regulating Sex Hormone Levels in Men
Poster Board MON-0005
Forty-four overweight and obese men aged 20-50 years (mean±SE: 35±1 years) were recruited from the community and underwent an overnight in-laboratory polysomnogram. SWA was computed as the average absolute spectral EEG power in the frequency band 0.75-4.5 Hz during non rapid eye movement (NREM) sleep, in the first 6 hours of sleep. Obstructive sleep apnea (OSA) was defined by an apnea-hypopnea index (AHI) ≥5. Total plasma testosterone was measured on the morning following the polysomnogram. Multivariate regression models were run to explore the predictors of SWA.
Obstructive sleep apnea was present in 66% of the men, and the median AHI was 16 (interquartile range 9-26) events/hour. In a model including only demographic characteristics, NREM SWA was negatively predicted by African-American race (β=-0.25, p<0.0001) and age (β=-0.03, p=0.004), but not BMI. When total testosterone was added, it improved the percentage of variance accounted for by the model and was independently and strongly associated with SWA (β=-0.75, p=0.005). In order to maintain statistical power, BMI was dropped from the last model, which examined the simultaneous contribution of AHI and total testosterone levels. In this model, the negative association of total testosterone (β=-0.56, p=0.02) and race (β=-0.26, p<0.0001) with NREM SWA persisted, whereas AHI (β=-0.11, p=0.08) and age (β=-0.02, p=0.08) only weakly predicted SWA.
In conclusion, in overweight and obese men under 50 years old, NREM SWA is negatively predicted by total circulating testosterone levels, in addition to race, age and AHI. These results have potential clinical implications as exogenous testosterone is being increasingly prescribed to middle-aged men.
Nothing to Disclose: LLM, KAT, FC, RL, DAE, EV, BM
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