Session: LBSU 1074-1087-Diabetes & Obesity
Poster Board LBSU-1076
We designed a prospective study to identify the relation between the gut microbiota composition and these metabolic conditions. 27 morbidly obese individuals, 26 patients with newly diagnosed diabetes and 28 healthy control subjects were included in the present study. Fecal samples of the participants were analyzed by quantitative real-time PCR for the presence of Bacteroidetes, Firmicutes, Bifidobacteria (Actinobacteria) and Clostridium Leptum (Firmicutes).
Bacteroidetes concentrations were similar between the three groups and there were no significant differences in the fecal Bifidobacteria, Firmicutes and Clostridium Leptum levels among the obesity and diabetic groups. However, Bifidobacteria, Firmicutes and Clostridium Leptum counts were significantly lower in patients with obesity and diabetes, compared to healthy control individuals. Logistic regression analysis showed that metabolic parameters, such as BMI and HbA1c, waist circumference and HbA1c, and finally weight and FBG were independent risk factors for reduced proportions of Firmicutes, Bifidobacteria and Clostridium Leptum, respectively.
These findings support that both obesity and diabetes may be associated with compositional changes in the intestinal microbial composition. All these results suggest that the gut microbiota can be used as an important marker, helping to determine the risk and etiopathogenesis of aforementioned metabolic disorders.
Nothing to Disclose: YB, AT, SEB, MAS, TT, CM, CH, KB, MD, FD, MY, AA, AS, OA
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