Session: L4-Friday Afternoon Plenary
Bone metastases, common in advanced malignancy, cause significant morbidity: pain, fracture, and muscle weakness. Tumor cells in bone disrupt normal bone remodeling to fuel a feed-forward cycle of bone destruction. Tumors stimulate osteoclastic bone resorption, to release growth factors from the bone matrix, which act on tumor cells to fuel production of more osteolytic factors. These factors act systemically to induce oxidation and weakness in skeletal muscle by specific molecular mechanisms to be discussed.