L4-1 Cancer, Bone and Muscle: Itís all about the Microenvironment

Program: Plenary
Session: L4-Friday Afternoon Plenary
Theresa Ann Guise, MD
Indiana University School of Medicine, Indianapolis, IN
Talk Description:

Bone metastases, common in advanced malignancy, cause significant morbidity: pain, fracture, and muscle weakness. Tumor cells in bone disrupt normal bone remodeling to fuel a feed-forward cycle of bone destruction. Tumors stimulate osteoclastic bone resorption, to release growth factors from the bone matrix, which act on tumor cells to fuel production of more osteolytic factors. These factors act systemically to induce oxidation and weakness in skeletal muscle by specific molecular mechanisms to be discussed.

Nothing to Disclose: TAG
See more of: Friday Afternoon Plenary
See more of: Plenary