L4-2 Defining the Genetic Basis of Benign and Malignant Adrenocortical Tumors

Program: Plenary
Session: L4-Friday Afternoon Plenary
Translational
Jerome Yves Bertherat, MD, PhD
INSERM U 1016, CNRS 8104, Institut Cochin, Paris Descartes University, Paris, France
Talk Description:

There is a variety of adrenocortical tumors that can be responsible for different cortisol excess levels. Genomics allowed recently many progress in this field. Bilateral tumors (macronodular and micronodular adrenal hyperplasia) are often caused by germline alterations (ARMC5, PRKAR1A). Unilateral tumors (adenoma or cancer) are caused by somatic alterations (CTNNB1, TP53, ZNRF3, MEN1, RB1, PRKACA, ). The importance of these advances for early diagnosis, tumors classification improvement, and development of new therapies will be discussed.

Disclosure: JYB: Advisory Group Member, atterocor, Investigator, Novartis Pharmaceuticals, Investigator, Ipsen.
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