Session: L6-Saturday Afternoon Plenary
A pivotal event in the onset of puberty in humans is the re-emergence of pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamic neurons. Pathways governing GnRH ontogeny and physiology have been discovered by studying animal models and humans with reproductive disorders. Recent human studies implicated the activation of the kisspeptin and its cognate receptor (KISS1- KISS1R), and the inactivation of the makoring ring finger 3 (MKRN3) in the premature reactivation of the GnRH secretion, causing central precocious puberty. In addition, epigenetic repression of key inibitory loci may play a fundamental role in the initiation of puberty.