L8-1 Mechanisms of Androgen Dependence in Progressive Prostate Cancer

Program: Plenary
Session: L8-Sunday Afternoon Plenary
Basic
Karen E Knudsen, PhD
Thomas Jefferson University, Philadelphia, PA
Talk Description:

There is increasing evidence that hormone action in cancer cells modulates the response to DNA damage. Conversely, a number of DNA repair factors have been found at sites of hormone receptor activity, suggesting that interplay between the DNA repair and hormone signaling pathways may have significant effects on the response to genomic insult and cancer cell survival. These mechanisms, and the therapeutic impact of hormone-DNA repair interplay, will be discussed.

Disclosure: KEK: Investigator, Celgene.
See more of: Sunday Afternoon Plenary
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