The Impact of Prenatal Parental Tobacco Smoking on Risk of Diabetes Mellitus in Middle-Aged Women

Program: Abstracts - Orals, Poster Previews, and Posters
Session: SAT 605-624-Genes, Metabolism, and Gestational Diabetes
Saturday, March 7, 2015: 1:00 PM-3:00 PM
Hall D-F, Diabetes (San Diego Convention Center)

Poster Board SAT-607
Michele La Merrill1, Piera Cirrillo2, Nickilou Krigbaum2 and Barbara Cohn3
1University of California, Davis, CA, 2Public Health Institute, 3Public Health Institute, Berkeley, CA
Growing evidence implicates prenatal tobacco smoke as a risk factor for obesity. The purpose of this study was to identify whether parental tobacco smoking during gestation influences risk of diabetes mellitus. This is a prospective study of 44 to 54 year old daughters (N = 1,801) born in the Child Health and Development Studies pregnancy cohort between 1959 and 1967. Their mothers resided near Oakland California, were members of the Kaiser Foundation Health Plan, and reported parental tobacco smoking during an early pregnancy interview.  Daughters reported physician diagnoses of diabetes mellitus and provided blood for hemoglobin A1C measurement. Prenatal maternal smoking had a stronger effect than prenatal paternal smoking on daughters’ diabetes mellitus risk, and the former persisted after adjustment for parental race, diabetes, and employment (aRR = 2.4 [95% confidence 1.4 - 4.1] p < 0.01 and aRR = 1.7 [95% confidence 1.0 – 3.0] p = 0.05, respectively]. Estimates of the effect of parental smoking were unchanged when further adjusted by daughters’ birth weight or current BMI. Maternal smoking was also a significant predictor of self-reported of type 2 diabetes diagnosis (2.3 [95% confidence 1.0 - 5.0] p < 0.05). Women with parents who smoked during pregnancy had increased risk of diabetes mellitus independent of known risk factors, providing further evidence that prenatal environmental chemical exposures independent of birth weight and current BMI can contribute to adult diabetes mellitus. While other studies seek to confirm our results, caution toward tobacco smoking by or proximal to pregnant women is warranted in diabetes mellitus prevention efforts.

Nothing to Disclose: ML, PC, NK, BC

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Sources of Research Support: National Institute of Environmental Health Sciences R00 ES019919 awarded to ML, the Eunice Kennedy Shriver National Institute of Child Health and Human Development HHSN275201100020C awarded to BC, and The California Breast Cancer Research Program Special Research Initiative 15ZB-0186 awarded to BC.