OR45-1 Lower Serum 25-Hydroxyvitamin D Is an Independent Predictor for Obesity but Not for Common Chronic Conditions: An Observational Study of African American and Caucasian Male Veterans

Program: Abstracts - Orals, Poster Previews, and Posters
Session: OR45-What Is New in Vitamin D?
Clinical/Translational
Sunday, March 8, 2015: 9:30 AM-11:00 AM
Presentation Start Time: 9:30 AM
Room 29 (San Diego Convention Center)
Jacqueline L. Cartier, MD1 and Elena Barengolts, MD2
1University of Illinois at Chicago, Chicago, IL, 2Jesse Brown VAMC, Chicago, IL
Background: The contribution of vitamin D insufficiency to the occurrence of common chronic conditions remains controversial.  African American men (AAM) have a higher risk of vitamin D insufficiency than Caucasian men (CAM) as well as a high burden of chronic disease yet they are relatively under-represented in research studies. 

Objective: The objective of the study was to examine whether vitamin D insufficiency was a predictor of prevalent and/or incident common chronic conditions in AAM and CAM.

Methods: 1,117 men were recruited at an urban VA medical center and followed prospectively. Vitamin D insufficiency was defined as 25(OH)D <30ng/ml. Chronic conditions that were evaluated included obesity (BMI >30kg/m2), type 2 diabetes (T2D), cardiovascular disease (CVD, including coronary artery disease [CAD], cerebrovascular accident [CVA], and congestive heart failure [CHF]), cancer (including lung, prostate, and colon), and fractures (traumatic and non-traumatic). Multivariate logistic regression was performed to determine predictors of prevalent common chronic conditions controlling for socio-demographic variables.

Results:This analysis was limited to 955 men (65.4% AAM, 27.2% CAM, 6.4% Hispanic, 0.4% Native American and 0.3% Asian) who had at least 1 yr of follow up (mean 5.4 yrs, range 1.0 – 7.1 yrs). Comparison of AAM vs CAM showed no differences in prevalent obesity (42 vs 41%), T2D (40 vs 35%), CVD (48 vs 50%) or cancer (33 vs 31%) but AAM had lower prevalence of fractures (11 vs 17%, p=0.01). Univariate analysis of the entire group showed 25(OH)D correlated with BMI as well as with T2D.  Serum 25(OH)D was not found to have a relationship with prevalent CVD (including separate analysis for CAD, CVA and CHF), cancer, fractures, and all-cause mortality. Multivariate analysis of the entire group identified 25(OH)D as an independent predictor of obesity, Odds Ratio (OR) (95% Confidence Interval) 0.962 (CI 0.949-0.976). The additional independent determinants of obesity included age (OR 0.975, CI 0.964-0.987) and current smoking (OR 0.446, CI 0.296-0.671).  Similar results were seen in AAM and CAM subgroups. The independent predictors of prevalent common chronic conditions (combined T2D, CVD and cancer) included increasing age (OR 1.095, CI 1.076-1.113), smoking (OR 1.577, CI 0.973-2.559), past alcohol use (OR 1.613, CI 1.085-2.397), past polysubstance use (OR 0.574, CI 0.382-0.863), and BMI (OR 1.054, CI 1.025-1.083) but not 25(OH)D.  Unexpectedly, there was a trend for higher 25(OH)D predicting fractures (p=0.063), probably explained by longer hours outside (and therefore higher sun exposure) spent in activities with higher risk of fractures.

Conclusion: Circulating 25(OH)D was an independent predictor for BMI but not for common chronic conditions in this urban population of male veterans. 

Nothing to Disclose: JLC, EB

*Please take note of The Endocrine Society's News Embargo Policy at https://www.endocrine.org/news-room/endo-annual-meeting

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