The Impact of Sleep Debt on Adiposity and Insulin Sensitivity in Patients with Early Diabetes

Program: Late-Breaking Abstracts
Session: LBT 097-116-Late-breaking Diabetes & Glucose Metabolism I
Translational
Thursday, March 5, 2015: 1:00 PM-3:00 PM
Hall D-F, Diabetes (San Diego Convention Center)

Poster Board LBT-112
Shahrad Taheri1, Teresa Arora1, Ashley R Cooper2, Robert Charles Andrews3 and Mimi Z Chen4
1Weill Cornell Medical College in Qatar, Doha, Qatar, 2University of Bristol, Bristol, United Kingdom, 3University of Bristol, Taunton, United Kingdom, 4University of Bristol, Oxford, United Kingdom
Objective

To cross-sectionally and prospectively assess potential associations between baseline weekday sleep debt and obesity, as determined by body mass index (BMI), as well as HOMA-insulin resistance in a large sample of newly diagnosed type 2 diabetes mellitus patients.

Methods

Participants (n=522), recruited into the Early Activity in Diabetes trial, were randomized into one of three groups (usual care, physical activity intervention or diet and physical activity intervention). Information was obtained at baseline and then at six and 12 months post-intervention. Seven-day sleep diaries were completed and weekday sleep debt calculated. Objective height (cm) was obtained at baseline and weight (kg) ascertained at all visits to determine obesity status (BMI ≥30kg/m2), and fasting blood samples were drawn to determine insulin resistance using a standardized technique.

Results

At baseline, compared to those without weekday sleep debt, those with positive weekday sleep debt were 72% more likely to be obese (OR=1.72 [95% CI: 1.03-2.88]). At six months post-intervention, positive weekday sleep debt was significantly associated with obesity and insulin resistance after adjustment, where OR=1.80 (95% CI: 1.05-3.08) and OR=2.04 (95% CI: 1.01-4.11), respectively. A further increase was observed, 12 months post-intervention, for positive weekday sleep debt with obesity and insulin resistance OR=1.83 (95% CI: 1.01-3.29) and OR=2.96 (95% CI: 1.31-6.67), respectively. For every 30 minutes of positive weekday sleep debt at baseline, the risk of obesity and insulin resistance at 12 months post-intervention was significantly increased by 17% and 39%, respectively.

Conclusion

The long-term effects of weekday sleep debt may cause metabolic disruption, which may exacerbate the progression of type 2 diabetes mellitus. Future interventions designed to slow progression, or reverse metabolic disease, should consider all factors that impinge on metabolic function. Consistent optimum sleep hygiene/education may be a key component for driving successful future trials in metabolic disease control.

Nothing to Disclose: ST, TA, ARC, RCA, MZC

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