L3-1 Nutrient Sensing Nuclear Receptors Coordinate Liver Energy Balance

Program: Plenary
Session: L3-Friday Morning Plenary
Basic
David D Moore, PhD
Baylor College of Medicine, Houston, TX
Talk Description:

The liver has fundamentally different functions in the fed and fasted states. We have found that opposite, but complementary effects of the nutrient sensing nuclear receptors PPARalpha and FXR maintain liver energy balance over this cycle. In the fasted liver, PPARalpha activation transcriptionally induces autophagy, recycling cellular components to provide energy. PPARalpha activation also represses the energy expensive liver secretome. In contrast, FXR activation in the energy replete fed state represses autophagy, but supports secretion.

Nothing to Disclose: DDM
See more of: Friday Morning Plenary
See more of: Plenary