Session: L3-Friday Morning Plenary
The liver has fundamentally different functions in the fed and fasted states. We have found that opposite, but complementary effects of the nutrient sensing nuclear receptors PPARalpha and FXR maintain liver energy balance over this cycle. In the fasted liver, PPARalpha activation transcriptionally induces autophagy, recycling cellular components to provide energy. PPARalpha activation also represses the energy expensive liver secretome. In contrast, FXR activation in the energy replete fed state represses autophagy, but supports secretion.