The theme of this session is non-neuronal cells in the brain that play important roles in regulating metabolism and energy balance. Endothelial cells make up fenestrated capillaries, and regulate how circulating signals such as leptin and ghrelin gain access to hypothalamic neurons. Glial-neuronal actions are crucial for appropriate neuroendocrine control, and emerging data suggests that glia “gate” energy sensing cues and can be the first responders to overnutrition. The speakers discuss new findings about how these non-neuronal cell types are implicated in novel aspects of neuroendocrine transport, inflammation, and response to circulating energy cues. The purpose of this session is to enhance meeting attendees understanding of how non-neuronal cells contribute to neuroendocrine control and how these cells may be important clinical targets for the future.