There are ~10 times more bacteria in our bodies than our own human cells, most of which reside in the gut. These bacteria, collectively referred to as the microbiome, along with viruses and other microorganisms, are increasing being linked to a variety of diseases including inflammatory bowel disease (IBD), cancer, diabetes and obesity. While it is not yet clear whether the microbes are drivers or passive players in these diseases, it is becoming increasing clear that there is a world of host-microbe interactions of which we were previously unaware. There is also emerging evidence that those interactions impact endocrine systems in our body and vice versa. This session will present just some of the latest findings on the topic.