Clinicopathological Characteristics and Prognostic Factors in Korean Patients with Medullary Thyroid Carcinoma; A Nationwide Multicenter Study

Program: Abstracts - Orals, Poster Previews, and Posters
Session: SAT 270-310-Thyroid Neoplasia (posters)
Clinical/Translational
Saturday, April 2, 2016: 1:15 PM-3:15 PM
Exhibit/Poster Hall (BCEC)

Poster Board SAT 292
Seo Young Oh*1, Bo Hyun Kim1, In Joo Kim1, Ji Yeong Seo1, Seok-Mo Kim2, Hang-Seok Chang2, Young Joo Park3, Do Joon Park3, Kyong Yeun Jung3, Sun Wook Kim4, Jae Hoon Chung4, Eun Kyung Jang5, Tae Yong Kim5, Hee Kyung Kim6, Jae Han Jeon7, Heung-Yong Jin8, Young Ha Baek8, Dong Jun Lim9, Eun Kyung Lee10, Su Kyoung Kwon11, Koon Soon Kim12 and Min Jin Lee13
1Pusan National University College of Medicine, Busan, South Korea, 2Yonsei University College of Medicine, Seoul, South Korea, 3Seoul National University College of Medicine, Seoul, South Korea, 4Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 5Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 6Chonnam National University College of Medicine, Gwangju, South Korea, 7Kyungpook National University School of Medicine, Daegu, South Korea, 8Chonbuk National University School of Medicine, Jeonju, South Korea, 9Seoul St. Mary’s Hospital, The Catholic University of Korea, College of Medicine, Seoul, South Korea, 10National Cancer Center, Goyang, South Korea, 11Kosin University College of Medicine, Busan, South Korea, 12Chungnam National University College of Medicine, Daejeon, South Korea, 13School of Medicine, Pusan National University, Busan, South Korea
Objective: Studies on the clinicopathological characteristics and prognostic factors of medullary thyroid carcinoma (MTC) in Korea are rare. The aim of this study is to evaluate these features for nationwide Korean patients with MTC.

Method: We enrolled 622 MTC patients who underwent surgery at 12 major tertiary medical centers from 1982 to 2013. We analyzed their gender, age at diagnosis, the pathologic findings, the TNM stage, the association with multiple endocrine neoplasia (MEN), RET protooncogene mutation. We also investigated the overall survival and the prognostic factors.

Result: The mean age at diagnosis of MTC was 47.6 years. In total, 434(69.8%) patients were female (male/female ratio, 1:2.3). Hereditary MTC comprised of 14.1% of the patients. The mean tumor size was 2.0cm (range 0.2-9.5cm). Fifty-eight percent of patients had the TNM stage more than III at the time of diagnosis. Distant metastasis was found in 7.9% (49/622) of the patients at the time of diagnosis. The most common metastatic sites were lung and bone (77.8%). RET protooncogene mutations were found in 30.1% (111/369) of the patients and 41.4% were in codon 634. The overall 5-year survival rate was 92.1% and the 5-year disease free survival rate was 87.5%. Extrathyroidal extension, age>40years and distant metastasis were the significant prognostic factors for survival by multivariate analysis (all P’s <0.05).

Conclusion:  This is the first nationwide multicenter study for clinicopathologic characteristics and prognostic factors in Korean patients with MTC. A better extensive information of clinical features and prognostic factors could improve the management and prognosis of MTC patients.

Nothing to Disclose: SYO, BHK, IJK, JYS, SMK, HSC, YJP, DJP, KYJ, SWK, JHC, EKJ, TYK, HKK, JHJ, HYJ, YHB, DJL, EKL, SKK, KSK, MJL

*Please take note of The Endocrine Society's News Embargo Policy at https://www.endocrine.org/news-room/endo-annual-meeting/pr-resources-for-endo