Session: SAT 270-310-Thyroid Neoplasia (posters)
Poster Board SAT 292
Method: We enrolled 622 MTC patients who underwent surgery at 12 major tertiary medical centers from 1982 to 2013. We analyzed their gender, age at diagnosis, the pathologic findings, the TNM stage, the association with multiple endocrine neoplasia (MEN), RET protooncogene mutation. We also investigated the overall survival and the prognostic factors.
Result: The mean age at diagnosis of MTC was 47.6 years. In total, 434(69.8%) patients were female (male/female ratio, 1:2.3). Hereditary MTC comprised of 14.1% of the patients. The mean tumor size was 2.0cm (range 0.2-9.5cm). Fifty-eight percent of patients had the TNM stage more than III at the time of diagnosis. Distant metastasis was found in 7.9% (49/622) of the patients at the time of diagnosis. The most common metastatic sites were lung and bone (77.8%). RET protooncogene mutations were found in 30.1% (111/369) of the patients and 41.4% were in codon 634. The overall 5-year survival rate was 92.1% and the 5-year disease free survival rate was 87.5%. Extrathyroidal extension, age>40years and distant metastasis were the significant prognostic factors for survival by multivariate analysis (all P’s <0.05).
Conclusion: This is the first nationwide multicenter study for clinicopathologic characteristics and prognostic factors in Korean patients with MTC. A better extensive information of clinical features and prognostic factors could improve the management and prognosis of MTC patients.
Nothing to Disclose: SYO, BHK, IJK, JYS, SMK, HSC, YJP, DJP, KYJ, SWK, JHC, EKJ, TYK, HKK, JHJ, HYJ, YHB, DJL, EKL, SKK, KSK, MJL
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