Session: SUN 176-202-Male Reproductive Endocrinology and Male Reproductive Tract (posters)
Bench to Bedside
Poster Board SUN 187
Aim and setting: The aim of the study was to investigate the relationship of RH with obesity, as assessed by body mass index (BMI) or waist circumference (WC), in a multi-ethnic cross-sectional cohort study from Manchester (UK) consisting of men of South Asian (SA), African Caribbean (AFC) or White European (WEU) origin participating in the HUSERMET project (4)
Methods: SA (n=180), AFC (n=166) and WEU (n=328) men aged 40-84 years from the general population had single morning blood samples measured for testosterone (T) (by LC MS/MS), SHBG, LH and FSH together with assessment of body composition, carbohydrate metabolism, hematological and cognitive parameters, and self-reported physical activity, sexual, physical, psychological symptoms and medical conditions. Relationships between RH (dependent variables) and BMI or WC (independent variables) were assessed using linear regression. Risk factors for low T levels, such as age, alcohol intake and physical activity were included as covariates. Five-fold cross-validation assessed whether the regressed relationships were robust.
Results: 642 men were included in the analysis (mean±sd age: 59±12 years, age-adjusted mean±se total T and calculated free T of SA, AFC and WEU men were: 14.0±0.4, 17.2±0.5, 17.1±0.3 nmol/L and 282.6±7.1, 314.1±7.6 and 313.3±5.4 pmol/L). For both AFC men and WEU men, BMI was a predictor of total T levels (AFC men: β:-0.36, 95%CI:-0.50;-0.22, and WEU men: β:-0.41, 95%CI:-0.52;-0.30,), calculated free T levels (AFC men: β:-0.24, 95%CI:-0.38;-0.11 and WEU men: β:-0.31, 95%CI:-0.42;-0.20), SHBG levels (AFC men: β:-0.27, 95%CI:-0.43,-0.10 and WEU men: β:-0.30, 95%CI:-0.40,-0.19, but not LH levels (AFC men: β:-0.14, 95%CI:-0.32;0.04, and WEU men: β:-0.07, 95%CI:-0.20;0.06) after full adjustment. However, in SA men, BMI was not related to RH, such as total T (β:-0.07, 95%CI:-0.24;0.09), calculated free T (β:-0.01, 95%CI:-0.17;0.16), SHBG (β:-0.10, 95%CI:-0.26;0.07) and LH levels (β:-0.05, 95%CI:-0.20;0.11) after full adjustment. Similar results were obtained, when using WC as a predictor. Five-fold cross validation displayed similar mean-squared error values across the 3 ethnic groups.
Conclusion: BMI and WC were significantly related to RH in AFC men and WEU men, but not in SA men. Therefore, an individual’s ethnic background should be taken into account when interpreting T results, especially in the context of obesity. Ethnic group – specific reference ranges for T may also need to be considered.
Disclosure: FCWW: Consultant, Repros Therapeutics, Investigator, Besins Healthcare, Speaker, Besins Healthcare. Nothing to Disclose: RJAHE, MKR, JDF, AS, PSG, AM, BGK, KC, GT, RG
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