Prevalence of Asthma in Reproductive-Aged Women with Polycystic Ovary Syndrome: New Results from the Australian Longitudinal Study on Women's Health

Program: Abstracts - Orals, Poster Previews, and Posters
Session: SAT 182-194-Hyperandrongenic Disorders and Female Reproductive Tract (posters)
Saturday, April 2, 2016: 1:15 PM-3:15 PM
Exhibit/Poster Hall (BCEC)

Poster Board SAT 186
Anju Elizabeth Joham*1, Barbora deCourten1, Lisa J Moran1, Deborah Loxton2 and Helena Jane Teede1
1Monash University, Melbourne, Australia, 2University of Newcastle, Australia
Context: Polycystic ovary syndrome (PCOS) affects 9-18% of reproductive-aged women. Recent research suggests that women with PCOS may have a higher prevalence of asthma (1); however there is limited literature exploring the association between asthma and PCOS is unclear.

Objective: To assess the prevalence of asthma and the impact of obesity on the prevalence of asthma in reproductive-aged women with and without PCOS in a community-based cohort.

Design: Cross-sectional analysis of data from a large longitudinal study (the Australian Longitudinal Study on Women’s Health (ALSWH)).

Setting: General community

Participants: Women were randomly selected from the national health insurance database. Standardised data collection occurred at 6 survey time points. Data from survey 4 (2006, n=9145, 62% of original cohort aged 18 to 23 years at survey 1) were examined for this study.

Main outcome measures: Self-reported PCOS and asthma

Results: In women aged 28 to 33 years, PCOS prevalence was 5.8% (95% CI: 5.3%-6.4%). The prevalence of asthma was 15.2% in women reporting PCOS and 10.6% in women not reporting PCOS respectively (p=0.004). Of women reporting asthma, mean BMI was significantly higher in women reporting PCOS compared with women not reporting PCOS (BMI 29.9 vs 27.7 kg/m2, p<0.001). Within each BMI category (healthy weight, overweight and obese), the proportion reporting asthma and T2DM was similar in women with PCOS than women without PCOS. After adjusting for age, BMI, PCOS and smoking status on multivariable regression analysis, PCOS was associated with increased odds of asthma (OR 1.34, 95% CI 1.004 – 1.79, p=0.047). BMI in the overweight and obese range were associated with increased odds of asthma (OR 1.24, 95% CI 1.02-1.50, p=0.03 and OR 1.77, 95% CI 1.46-2.15, p<0.001) respectively.

Conclusions: In a large community-based cohort of reproductive-aged women, PCOS status and BMI in both the overweight and obese categories were independently associated with asthma.

Hart R, Doherty DA. The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage. J Clin Endocrinol Metab. 2015;100(3):911-9.

Nothing to Disclose: AEJ, BD, LJM, DL, HJT

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