Idiopathic Osteoporosis: Premenopausal Severe Osteoporosis with Fractures Detected Following IVF Induced Pregnancy

Program: Abstracts - Orals, Poster Previews, and Posters
Session: FRI 368-390-Metabolic Bone Disease Case Reports (posters)
Clinical
Friday, April 1, 2016: 1:15 PM-3:15 PM
Exhibit/Poster Hall (BCEC)

Poster Board FRI 385
Levent Ozsari*1, Seyid Ahmet Ay2, Ferhat Deniz2, Kamil Baskoy2 and Arif Yonem2
1Diyarbakir Military Hospital, Diyarbakir, Turkey, 2GATA Haydarpasha Training Hospital, Istanbul, Turkey
Background: Premenopausal osteoporosis is a rare condition among young women. Idiopathic osteoporosis is the most frequent cause of premenopausal osteoporosis. Our case, severe osteoporosis with fractures detected following IVF induced pregnancy, is the first in literature according to our search.

Clinical case: A 34-year-old primipara woman was admitted to our clinic because of previous osteoporosis. The history of osteoporosis dated back to her pregnancy when she was 24 years old. She became pregnant after in vitro fertilization (IVF) therapy that she couldn’t remember which medications were applied. At the first month of pregnancy she had back pain that was supposed to be related with the pregnancy and no further investigation was done. Her back pain was intensified after delivery. In postnatal 3rd month, bone mineral densitometry (BMD) showed advanced osteoporosis (Z score of vertebra and trochanter were -4.5) and conventional radiographies showed compression fractures at thoracic 7., 8., 9. and 10. vertebrates. She had surgery for vertebral stabilization. Further investigations with biochemistry and hormones showed no abnormality. Serum vitamin D, calcium, PTH, phosphorous and magnesium levels were normal. Antiresorptive therapy was started and went on total 5 years with the irregular use of bisphosphonate, calcitonin and calcium plus vitamin D. Family history of the patient did not add much information neither of her mother nor female relatives with osteoporosis. Physical examination was unremarkable. She did not have any complain related to osteoporosis at the last visit. Last BMD showed Z score lumber -2.5 and trochanter -1.2 which was consistent with osteoporosis and osteopenia. We advised her to have yearly follow-up.

Conclusion: Even described after IVF therapy, the etiology of this premenopausal osteoporosis may be lactation associated or idiopathic osteoporosis.

Nothing to Disclose: LO, SAA, FD, KB, AY

*Please take note of The Endocrine Society's News Embargo Policy at https://www.endocrine.org/news-room/endo-annual-meeting/pr-resources-for-endo