Session: SAT 270-310-Thyroid Neoplasia (posters)
Poster Board SAT 299
Methods: DTC patients younger than 18 years of age at diagnosis were selected from a cohort of 880 DTC patients attending the Thyroid Clinic, at a tertiaryuniversity–based hospital. Baseline clinical and oncological characteristics, interventions, disease status and outcomes are described. The sTg was evaluated through the area under the ROC curve, using sTg as a continuous prognostic variable and disease status at follow-up as the outcome variable.
Results: A group of 30 children and adolescents with DTC, composed by 25 (83.3%) girls and mean age at diagnosis of 14.6 ± 3.3 years, were included in this report. Twenty-nine (96.7%) patients had papillary thyroid carcinoma, presenting a median tumor size of 2.2 cm (P25-75 1.7-3.5), cervical metastasis in 19 (63.3%) and distant metastasis in 4 (13.3%) patients. Regarding the TNM stage, 26 (86.7%) were in stage I and 4 (13.3%) in stage II. All patients underwent total thyroidectomy and 27 (90.0%) received radioactive iodine (RAI) therapy (median dose of 100 mCi, P25-75 100-150). After a median follow-up of 5.0 years (P25-75 3.0-9.8), 15 (62.5%) patients are considered disease free, 5 (20.8%) have with biochemical persistent disease and 4 (16.7%) persistent structural disease. The post-operative sTg cut-off of 12 ng/ml had a sensitivity of 100% and a specificity of 90% to predict disease free status, with an area under the ROC curve of 0.99 (CI 0.95-1.00), P<0.001.
Conclusion: Our data demonstrated that sTg seems to be a useful prognostic factor for DTC in children and adolescents. Of special interest is that the optimal sTg cut-off point of 12 ng/ml for this population is higher than that obseverd in the adult population.
Nothing to Disclose: JMSD, ABZ, RSS, ALM
*Please take note of The Endocrine Society's News Embargo Policy at https://www.endocrine.org/news-room/endo-annual-meeting/pr-resources-for-endo
See more of: Abstracts - Orals, Poster Previews, and Posters