Session: SAT 270-310-Thyroid Neoplasia (posters)
Poster Board SAT 295
Aim: Our aim was to compare the epidemiological characteristics of CT and incidence rates according to mechanism of detection in a university hospital-based HMO of Buenos Aires in two different periods.
Materials and Methods: Design: Observational, retrospective cohort. Methods: Our HMO comprises a significant sample of the population of Buenos Aires and its suburbs. All its members undergo surgery only in the same Medical Center, where all medical records are electronically managed since 2003. We identified incident cases of TC in our HMO through de Pathology Division records. Complete medical records of cases were then reviewed by the authors to valídate them as true incident TC, and to identify mechanisms of detection, clinical and pathologic characteristics. The Affiliation Registry was accessed to valídate affiliation and to calculate the population at risk at the time of diagnosis. Patients with less tan 12 months´ affiliation prior to diagnosis were excluded of análisis. TC incidence and characteristics were grouped in two periods 2003-2007 and 2008-2013 for comparison. . Incidence rates and incidence rate relative risk (IRR) according to mechanism of detection were estimated for each period , and age-adjusted to the world population. 95% confidence intervals were calculated for each rate. Quantitative variables were expressed as X+SDM or Median (IQR); qualitative variables were expressed in numbers (%). Incidence rates are expressed as 100000 person/year. Two tailed t- tests, X2 tests or 95% Confidence Intervals were used to compare both periods as appropiate. A p<0.05 was considered significant.
Results: 224 patients belonging to the HMO underwent surgery for TC between January 1st , 2003 and December 31st , 2013. The mean age at diagnosis 57 + 14 years; 81% were female, with a F/M ratio of 4.33; 88% were papillary thyroid carcinomas. The crude cumulative incidence rate for the period of 2008-2013 was 22.6 [19.47-26.15], which adjusted to world population (WHO 2001) was 16.01 (13.36-18.65). Incident TC was significantly smaller (10 [6-17] vs 14 [9-20] mm] (p<0.03) and incidental TC IRR was significantly higher [0.42 [0.301-0.57] vs 0.12 [0.04-0.30]] during 2008-2013 when compared to 2003-2007.
Conclusions: There has been an increase of the incidence rate of incidental TC, mainly of smaller sized- TC,i n the population belonging to this HMO of Buenos Aires, which suggests an excess of detection of subclinical disease. More studies are needed to confirm these results in other settings
Nothing to Disclose: MFR, JV, CG, CG, AJ, CC, SF, MF, PF
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