Session: SUN 176-202-Male Reproductive Endocrinology and Male Reproductive Tract (posters)
Bench to Bedside
Poster Board SUN 192
Clinical case: A 19 years old male was attended to our clinic with hypogonadism and uncontrolled diabetes mellitus (DM). He was diagnosed with hypergonadotropic hypogonadism and Klinefelter syndrome (47, XXY) in another institute. He was treated with antidepressant for a year. Insulin dependent DM was diagnosed at the age of seven. He had a strong family history on infertility and DM; one brother with hypogonadism, one sister with primary amenorea (no ovum found) and revealed two siblings with insulin dependent DM since childhood. Physical examination revealed obese habitus (BMI: 28.1 kg/m2), secondary sex characters were poor, gynecoid type body, bilateral gynecomastia, hypoplasic and tough testicles. T therapy was not started before. He was under intensive insulin therapy. Gonadotropins were high and total testosterone was low. We began T (Sustanon® 250 mg. intramuscular injection, twice a month). Facial acne, nervousness and agitation were found at the second month of the therapy. Frequency of T therapy was decreased to once a month and antidepresant therapy was started. He attempted suicide with fail at the third month of T therapy. His anxiety relieved after antidepressant dose increment and T therapy cessation.
Conclusion: Even T therapy prevent patients with Klinefelter syndrome from osteoporosis and improve their mental status, it may bring harmful events like suicidal attempt.
Nothing to Disclose: LO, IK, MI
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