Suicide Attempt Following Testosterone Therapy Patient with Klinefelter Syndrome

Program: Abstracts - Orals, Poster Previews, and Posters
Session: SUN 176-202-Male Reproductive Endocrinology and Male Reproductive Tract (posters)
Bench to Bedside
Sunday, April 3, 2016: 1:15 PM-3:15 PM
Exhibit/Poster Hall (BCEC)

Poster Board SUN 192
Levent Ozsari*1, Irfan Kucuk2 and Mehmet Isintas2
1Diyarbakir Military Hospital, Diyarbakir, Turkey, 2Diyarbakir Military Hospital, Diyarbakır, Turkey
Background: Klinefelter syndrome is a genetic disorder associated with extra X chromosome, male hypogonadism and atypical social-behaviours. Testosterone therapy is recommended for the treatment of hypogonadism. This therapy improves neurodevelopment and prevents osteoporosis. However, suicidal attempt following T therapy has not been reported yet.

Clinical case: A 19 years old male was attended to our clinic with hypogonadism and uncontrolled diabetes mellitus (DM). He was diagnosed with hypergonadotropic hypogonadism and Klinefelter syndrome (47, XXY) in another institute. He was treated with antidepressant for a year. Insulin dependent DM was diagnosed at the age of seven. He had a strong family history on infertility and DM; one brother with hypogonadism, one sister with primary amenorea (no ovum found) and revealed two siblings with insulin dependent DM since childhood. Physical examination revealed obese habitus (BMI: 28.1 kg/m2), secondary sex characters were poor, gynecoid type body, bilateral gynecomastia, hypoplasic and tough testicles. T therapy was not started before. He was under intensive insulin therapy. Gonadotropins were high and total testosterone was low. We began T (Sustanon® 250 mg. intramuscular injection, twice a month). Facial acne, nervousness and agitation were found at the second month of the therapy. Frequency of T therapy was decreased to once a month and antidepresant therapy was started. He attempted suicide with fail at the third month of T therapy. His anxiety relieved after antidepressant dose increment and T therapy cessation.

Conclusion: Even T therapy prevent patients with Klinefelter syndrome from osteoporosis and improve their mental status, it may bring harmful events like suicidal attempt.

Nothing to Disclose: LO, IK, MI

*Please take note of The Endocrine Society's News Embargo Policy at https://www.endocrine.org/news-room/endo-annual-meeting/pr-resources-for-endo