PP14-4 Dietary Calcium Intake and Risk of Cardiovascular Disease, Stroke, and Fracture in a Low Calcium Intake Population: A Prospective Community-Based Cohort Study

Program: Abstracts - Orals, Poster Previews, and Posters
Session: PP14-Disorders of Phosphate Metabolism and Metabolic Bone Disease
Basic/Translational
Saturday, April 2, 2016: 11:30 AM-11:45 AM
Room 104 (BCEC)

Poster Board SAT 325

Health Disparities
Sung Hye Kong*1, Jung Hee Kim2, A Ram Hong3, Nam H Cho4 and Chan Soo Shin2
1Seoul National University College of Medicine, 2Seoul National University College of Medicine, Seoul, South Korea, 3Seoul National University College of Medicine, South Korea, Seoul, 4Ajou University School of Medicine
Objective: The role of dietary calcium intake in cardiovascular disease (CVD), stroke and fracture is controversial. Moreover, study subjects in previous studies were from high calcium intake populations. We aimed to evaluate whether high dietary calcium intake increases the risk of CVD, stroke, and fracture in a low calcium intake population.

Method: The present study was conducted in the Ansung and Ansan Cohort Study, the ongoing prospective community-based cohort study since 2001 in Korea. A total of 9,631 subjects (4,589 men and 5,042 women) aged over 40 years at baseline were followed up for a mean of 13 years. Of them, 2199 men over 50 years and 2704 postmenopausal women without previous CVD and stroke were included in the final analysis. Dietary food intake was assessed by repeated food frequency questionnaires. CVD, stroke and fracture events were ascertained from the interview in biennial examination. Hazard ratios (HR) with 95% confidence interval (CI) were estimated from cox regression analysis for CVD, stroke, and fracture after adjusting for age, body mass index, vegetable and fruit intake, protein and sodium intake, physical activity, drinking and smoking status, history of diabetes and hypertension, and total energy from the diet.

Result: Study subjects were classified into quartiles based on baseline energy-adjusted calcium intake (median, interquartile range): quartile 1 (234, 151 mg/d), quartile 2(310, 158 mg/d), quartile 3 (439, 158 mg/d), quartile 4 (742, 273 mg/d). The incidence of CVD, stroke, and fracture were 1,976 (40.3%), 1,854 (37.8%), 572 (11.7%). Comparing with the first quartile of energy-adjusted calcium intake, the HRs (95% CI) for CVD were 0.762 (0.670-0.866) for quartile 2, 0.656 (0.570-0.754) for quartile 3, 0.524 (0.441-0.624) for quartile 4, respectively. Similarly, high dietary calcium intake decreased the risk of stroke. The HRs (95% CI) compared with the first quartile were 0.762 (0.670-0.866) for quartile 2, 0.656 (0.570-0.754) for quartile 3, 0.524 (0.441-0.624) for quartile 4, respectively. Fracture risk was not reduced across the quartiles of dietary calcium intake. The HRs (95% CI) were 1.015 (0.797-1.291) for quartile 2, 0.966 (0.749-1.244) for quartile 3, 0.760 (0.553-1.044) for quartile 4 compared with the quartile 1.

Conclusion: In older men and postmenopausal women in a low dietary calcium intake population, higher dietary intake of calcium was associated with decreased risk of CVD and stroke. Risk of fracture was not significantly associated with dietary calcium intake.

Nothing to Disclose: SHK, JHK, ARH, NHC, CSS

*Please take note of The Endocrine Society's News Embargo Policy at https://www.endocrine.org/news-room/endo-annual-meeting/pr-resources-for-endo